Gastrointestinal (GI) side results prevail and have included nausea (2 % to 11 %); heartburn (11 %); irregularity (3.3 % or less); abdominal pain, looseness of the bowels, completely dry mouth, dyspepsia, as well as flatulence (3 % or much less); abdominal cramps (2 % or much less); eructation, gastroesophageal reflux, gingival hyperplasia, melena, preference perversion, and also throwing up (1 % or much less); as well as dysphagia, esophagitis, GI ailment, GI hemorrhage, GI irritation, gum condition, and gum hemorrhage (less than 1 %). Hardly ever, bezoars have been reported in patients taking extended release nifedipine (the energetic component included in Adalat) as Procardia XL(R). Gastrointestinal blockage resulting in a hospital stay as well as surgical treatment (consisting of the requirement for bezoar removal) has actually been stated with Procardia XL(R), also in clients without any recognized intestinal condition. Tablet adherence to the GI wall surface with ulcer has actually been stated with Procardia XL(R); some instances required a hospital stay and also treatment. [Ref]

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Hepatic negative side effects have actually consisted of raised GGT (much less compared to 1 %); transient elevations of liver feature tests and also uncommon cases of hepatitis (approximately 0.5 %); hypersensitive liver disease (less compared to 0.5 %); and also jaundice. [Ref]

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Nifedipine-associated liver disease is dose-dependent, distinctive, and also believed to be because of hypersensitivity since it is usually linked with fever, eosinophilia, rash, and also joint inflammation. One instance of alcoholic-like liver sores, consisting of steatosis as well as Mallory physical bodies, has actually been associated with using nifedipine. Some researches have revealed that nifedipine could raise hepatic portal venous high blood pressure, which may be very important in patients with serious liver disease. Constant tracking of liver function examinations during nifedipine therapy is advised in clients with underlying liver disease. [Ref]